In the US, LSD is not permitted. The federal government has not allowed researchers to conduct trials for scientific objectives. Consequently, compared to other psychedelics, its therapeutic potential has received far less research.

Read More: Where to get LSD

Nevertheless, before to being included to Schedule 1, LSD was investigated a little between the 1950s and the 1970s. It was investigated at this time for the treatment of addiction, psychosomatic (mind/body) disorders, anxiety, and depression. Recent scientific study has not entirely demonstrated its usefulness.

Clinical studies were carried out in the United States from 1963 to 1976 at the Maryland Psychiatric Research Center in Baltimore. During that time, 700 individuals received treatment for depression and anxiety, with generally positive outcomes. Due to stricter laws governing human trials and a shortage of federal money, this institution was the last in the country to discontinue its clinical study with LSD.

Clinical LSD research has resumed in Europe during the past ten years, with studies conducted in Switzerland and the UK. In addition to its potential for healing, LSD has proven helpful in understanding how the brain functions when paired with contemporary brain imaging techniques.

What is the purported benefit of LSD?

Only a small number of experimental trials have been carried out in the previous 25 years, despite the fact that various investigations employing LSD were carried out in the middle of the 20th century. The most comprehensive analysis of the literature found evidence supporting LSD’s potential benefits as an alcohol use disorder therapy.

The findings also imply that, generally speaking, people experiencing anxiety associated with serious disease, depression, or addiction may benefit from a few single doses of LSD administered in a medical context. According to one research, LSD can significantly and durably reduce symptoms of anxiety and sadness for up to 16 weeks.

While these findings are promising, additional investigation is required to validate these results and the therapeutic use of LSD in psychiatry. Concerns over LSD and its potential as a therapy were highlighted in 2022 by a study of the scientific trials of psychedelic drugs investigated for mental health and substance use issues. According to the reviewers, no LSD experiment has fulfilled the anticipated scientific requirements.

How about a little dose? What is the purpose of it?

Because LSD is such a strong psychedelic, even minute doses of it can have an impact. A typical recreational dosage of LSD is in the range of 100–200μg, which is equivalent to 0.1–0.2 mg (1μg is one millionth of a gram). Contrast this with an ordinary aspirin’s 325 mg of active substance. Therefore, a microdose is ten to twenty micrograms of LSD.

People who took LSD microdoses reported improvements in their mood, creativity, and thinking, according to a number of recent European research. It also improved energy and friendliness and decreased worry.

In one of these investigations, scientists measured elevated alterations in a blood marker associated with neuroplasticity—the brain’s capacity to remodel itself. Often, these adjustments are necessary to manage depression effectively.

Nonetheless, several researchers have shown that giving placebo recipients a little dose of LSD has comparable beneficial effects. Placebos are chemicals, such as sugar pills, that have no physiological impact. These findings have prompted some to argue that the benefit of microdosing lies not in the microdose itself, but rather in the expectation that something will improve.

Experts concur that further study on microdosing is necessary in light of the encouraging preliminary findings.